Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 19/20 | 0.69 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3886215 | 0.93 | AURKA (0.65) | AURKAKITFLT3 | |
| SCHEMBL3879764 | 0.91 | AURKA (0.64) | AURKAKITFLT3 | |
| SCHEMBL3887853 | 0.89 | AURKA (0.81) | AURKAKITFLT3 | |
| SCHEMBL6374740 | 0.89 | AURKA (0.66) | AURKAKIT | |
| SCHEMBL3880769 | 0.82 | AURKA (0.80) | AURKAKITFLT3 | |
| SCHEMBL3879279 | 0.81 | AURKA (1.00) | AURKA | |
| SCHEMBL3887141 | 0.80 | AURKA (0.78) | AURKA | |
| SCHEMBL3880586 | 0.80 | AURKA (0.71) | AURKAKIT | |
| SCHEMBL6376887 | 0.79 | SMN1; SMN2 (0.52) | AURKAFLT3 | |
| SCHEMBL3883428 | 0.79 | AURKA (0.77) | AURKAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534716-B1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-04-23 | — | — | EP | disclosed |
| EP-1534716-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004007504-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-01-22 | — | — | WO | disclosed |