Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KDM6A | O15550 | 2/20 | 0.55 |
| ▸ | KDM6B | O15054 | 2/20 | 0.55 |
| ▸ | KDM5C | P41229 | 2/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.55 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.55 |
| ▸ | TET3 | O43151 | 1/20 | 0.55 |
| ▸ | KDM4A | O75164 | 1/20 | 0.55 |
| ▸ | KDM4B | O94953 | 1/20 | 0.55 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.55 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155477 | 0.83 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL11806642 | 0.78 | KDM4E (0.68) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL11801910 | 0.76 | KDM4E (0.68) | KDM4EL3MBTL1NPC1RAB9AKDM6A | |
| SCHEMBL4698503 | 0.75 | PDE4D (0.67) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL27380391 | 0.74 | KDM6A (0.66) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL27380383 | 0.73 | KDM6A (0.65) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL27468637 | 0.73 | KDM4E (0.77) | PDE4DKDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL6068195 | 0.72 | KDM4E (1.00) | KDM4EL3MBTL1NPC1RAB9AKDM6A | |
| SCHEMBL29349767 | 0.72 | KDM4E (1.00) | KDM4EL3MBTL1NPC1RAB9AKDM6A | |
| SCHEMBL27380394 | 0.72 | KDM6A (0.62) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | claimed |
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |