Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 20/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15680661 | 0.87 | HDAC8 (0.71) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL443904 | 0.83 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL442640 | 0.82 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL445295 | 0.81 | HDAC8 (1.00) | HDAC8HDAC6 | |
| SCHEMBL443071 | 0.80 | HDAC8 (1.00) | HDAC8HDAC6 | |
| SCHEMBL355809 | 0.79 | HDAC8 (0.76) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL445406 | 0.79 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL10253392 | 0.79 | HDAC8 (0.80) | HDAC8HDAC6 | |
| SCHEMBL447086 | 0.79 | HDAC8 (0.80) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL444505 | 0.76 | HDAC8 (1.00) | HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012031993-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |