Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.89 |
| ▸ | CTSD | P07339 | 11/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698235 | 0.94 | BACE1 (1.00) | BACE1CTSDCYP3A4 | |
| SCHEMBL5578973 | 0.89 | BACE1 (0.84) | BACE1CTSDCYP3A4 | |
| SCHEMBL4702961 | 0.85 | BACE1 (0.75) | BACE1CTSDCYP3A4 | |
| SCHEMBL6701304 | 0.85 | BACE1 (0.68) | BACE1CTSDCYP3A4 | |
| SCHEMBL6701309 | 0.85 | BACE1 (0.68) | BACE1CTSDCYP3A4 | |
| SCHEMBL4819310 | 0.84 | BACE1 (0.64) | BACE1CTSDCYP3A4 | |
| SCHEMBL3355039 | 0.83 | BACE1 (0.78) | BACE1CTSDCYP3A4 | |
| SCHEMBL3355037 | 0.83 | BACE1 (0.78) | BACE1CTSDCYP3A4 | |
| SCHEMBL4819302 | 0.83 | BACE1 (0.69) | BACE1CTSDCYP3A4 | |
| SCHEMBL5579109 | 0.82 | BACE1 (0.86) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937638-A1 | METHODS OF TREATING AMYLOIDOSIS USING ARYL-CYCLOPROPYL DERIVATIVE ASPARTYL PROTEASE INHIBITORS | Elan Pharmaceuticals Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007047306-A1 | METHODS OF TREATING AMYLOIDOSIS USING ARYL-CYCLOPROPYL DERIVATIVE ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |