Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3508232 | 0.95 | EGFR (0.58) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL4697984 | 0.83 | EGFR (0.57) | EGFRERBB2ERBB4ERBB3HDAC3 | |
| SCHEMBL1094486 | 0.81 | EGFR (0.68) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL5528646 | 0.80 | EGFR (0.66) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL5524423 | 0.80 | EGFR (0.80) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL14466953 | 0.76 | EGFR (0.68) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL2746982 | 0.75 | EGFR (0.64) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL5002106 | 0.75 | EGFR (0.82) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL1105295 | 0.75 | EGFR (0.82) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL5002100 | 0.75 | EGFR (0.82) | EGFRERBB2ERBB4ERBB3GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987037-A2 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007097470-A2 | FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-30 | — | — | WO | disclosed |