Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 20/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774250 | 1.00 | HRH4 (0.62) | HRH4HRH3KCNH2 | |
| SCHEMBL1774623 | 0.90 | HRH4 (0.48) | HRH4HRH3 | |
| SCHEMBL1774585 | 0.90 | HRH4 (0.48) | HRH4HRH3 | |
| SCHEMBL1774592 | 0.88 | HRH4 (0.66) | HRH4 | |
| SCHEMBL1774402 | 0.83 | HRH4 (0.68) | HRH4HRH3KCNH2 | |
| SCHEMBL18601594 | 0.83 | HRH4 (0.68) | HRH4HRH3KCNH2 | |
| SCHEMBL18601595 | 0.83 | HRH4 (0.68) | HRH4HRH3KCNH2 | |
| SCHEMBL1774816 | 0.82 | HRH4 (0.67) | HRH4HRH3KCNH2 | |
| SCHEMBL1774331 | 0.82 | HRH4 (0.68) | HRH4HRH3KCNH2 | |
| SCHEMBL1775267 | 0.82 | HRH4 (0.68) | HRH4HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| EP-1966162-A2 | PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007072163-A2 | PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |