Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576261 | 0.78 | NTRK1 (0.49) | NTRK1NUAK1IGF1RPIK3C3 | |
| SCHEMBL56675 | 0.78 | NTRK1 (0.53) | NTRK1IGF1RPIK3C3CCNA2CDK2 | |
| SCHEMBL56941 | 0.77 | NTRK1 (0.60) | NTRK1IGF1RPIK3C3CCNA2CDK2 | |
| SCHEMBL2570471 | 0.76 | NTRK1 (0.51) | NTRK1NUAK1IGF1RPIK3C3 | |
| SCHEMBL4103550 | 0.75 | NTRK1 (0.56) | NTRK1IGF1R | |
| SCHEMBL4103556 | 0.75 | NTRK1 (0.56) | NTRK1IGF1R | |
| SCHEMBL2634428 | 0.73 | NTRK1 (0.71) | NTRK1IGF1R | |
| SCHEMBL3137277 | 0.72 | NUAK1 (0.56) | NTRK1NUAK1IGF1RPIK3C3 | |
| SCHEMBL57082 | 0.72 | NTRK1 (0.49) | NTRK1IGF1RPIK3C3CCNA2CDK2 | |
| SCHEMBL56561 | 0.71 | NTRK1 (0.54) | NTRK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |