Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 11/20 | 0.39 |
| ▸ | DRD2 | P14416 | 10/20 | 0.39 |
| ▸ | HTR2A | P28223 | 9/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4578951 | 0.88 | HDAC1 (0.44) | HDAC1HDAC2CHRM4MCHR1RHOA | |
| SCHEMBL4579158 | 0.86 | HDAC1 (0.45) | HDAC1HDAC2MCHR1RHOAHDAC3 | |
| SCHEMBL4579949 | 0.79 | HDAC1 (0.41) | HDAC1HDAC2MCHR1HDAC3 | |
| SCHEMBL4578187 | 0.79 | HDAC1 (0.44) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4579714 | 0.77 | HDAC1 (0.44) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4578792 | 0.77 | HDAC1 (0.48) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4579958 | 0.75 | HDAC1 (0.61) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4578547 | 0.73 | HDAC1 (0.43) | HDAC1HDAC2HDAC3BCHE | |
| SCHEMBL4579959 | 0.72 | HDAC1 (0.41) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4580090 | 0.72 | HDAC1 (0.59) | HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007720-A1 | BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118137-A1 | BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2007-10-18 | — | — | WO | disclosed |