Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 1.00 |
| ▸ | PDE4A | P27815 | 19/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 19/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 19/20 | 1.00 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698785 | 0.89 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4698780 | 0.87 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4698349 | 0.85 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4701166 | 0.84 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL1554338 | 0.84 | PDE4D (0.85) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4755271 | 0.84 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4702803 | 0.83 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL29993300 | 0.83 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4700491 | 0.83 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4701277 | 0.83 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | claimed |
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |