Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699480 | 0.91 | GRM5 (0.81) | GRM5 | |
| SCHEMBL14438143 | 0.85 | GRM5 (0.72) | GRM5 | |
| SCHEMBL13683968 | 0.84 | GRM5 (1.00) | GRM5 | |
| SCHEMBL4703859 | 0.83 | GRM5 (0.77) | GRM5 | |
| SCHEMBL3374172 | 0.83 | GRM5 (0.71) | GRM5 | |
| SCHEMBL4698881 | 0.82 | GRM5 (0.69) | GRM5 | |
| SCHEMBL13683965 | 0.82 | GRM5 (1.00) | GRM5 | |
| SCHEMBL13683984 | 0.81 | GRM5 (1.00) | GRM5 | |
| SCHEMBL660500 | 0.81 | GRM5 (1.00) | GRM5 | |
| SCHEMBL13069325 | 0.81 | GRM5 (1.00) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434773-B1 | HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | claimed |
| US-7253190-B2 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253190-B2 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | disclosed |