Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706569 | 0.91 | BDKRB1 (0.51) | BDKRB1ITGB1ITGA4ITGB7NPC1 | |
| SCHEMBL4705689 | 0.91 | BDKRB1 (0.52) | BDKRB1SMN1; SMN2JAK2TYK2ALDH1A1 | |
| SCHEMBL4705722 | 0.88 | BDKRB1 (0.48) | BDKRB1ITGB1ITGA4ITGB7NPC1 | |
| SCHEMBL6045814 | 0.87 | BDKRB1 (0.69) | BDKRB1SMN1; SMN2NPC1RAB9AJAK2 | |
| SCHEMBL4704544 | 0.86 | BDKRB1 (0.44) | BDKRB1SMN1; SMN2ITGB1ITGA4ITGB7 | |
| SCHEMBL4705143 | 0.86 | BDKRB1 (0.49) | BDKRB1ITGB1ITGA4ITGB7NPC1 | |
| SCHEMBL4789665 | 0.85 | BDKRB1 (0.53) | BDKRB1 | |
| SCHEMBL4788480 | 0.85 | BDKRB1 (0.43) | BDKRB1SMN1; SMN2ITGB1ITGA4ITGB7 | |
| SCHEMBL4706254 | 0.84 | BDKRB1 (0.46) | BDKRB1ITGB1ITGA4ITGB7NPC1 | |
| SCHEMBL4702475 | 0.84 | BDKRB1 (0.42) | BDKRB1SMN1; SMN2ITGB1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |