Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 12/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789234 | 0.88 | BDKRB1 (0.52) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4702172 | 0.87 | BDKRB1 (0.47) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4788480 | 0.84 | BDKRB1 (0.43) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4703365 | 0.83 | BDKRB1 (0.46) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4790151 | 0.83 | BDKRB1 (0.61) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4789160 | 0.83 | BDKRB1 (0.61) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4704918 | 0.83 | BDKRB1 (0.46) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4701941 | 0.83 | BDKRB1 (0.44) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4704300 | 0.83 | BDKRB1 (0.50) | BDKRB1HPGDSMN1; SMN2F2MAPT | |
| SCHEMBL4701888 | 0.82 | BDKRB1 (0.45) | BDKRB1HPGDSMN1; SMN2F2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |