Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 14/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | BCL9 | O00512 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646522 | 1.00 | DPP4 (0.53) | DPP4DPP9PTGDR2EPHX2BCL9 | |
| SCHEMBL646857 | 1.00 | DPP4 (0.53) | DPP4DPP9PTGDR2EPHX2BCL9 | |
| SCHEMBL647435 | 0.86 | DPP4 (0.58) | DPP4DPP9EPHX2DPP8 | |
| SCHEMBL647594 | 0.85 | DPP4 (0.55) | DPP4DPP9EPHX2DPP8 | |
| SCHEMBL647580 | 0.84 | DPP4 (0.53) | DPP4DPP9EPHX2DPP8 | |
| SCHEMBL648583 | 0.84 | DPP4 (0.53) | DPP4DPP9EPHX2DPP8 | |
| SCHEMBL4756036 | 0.84 | DPP4 (0.53) | DPP4DPP9EPHX2DPP8 | |
| SCHEMBL648116 | 0.83 | DPP4 (0.62) | DPP4DPP9EPHX2DPP8 | |
| SCHEMBL647636 | 0.83 | DPP4 (0.62) | DPP4DPP9EPHX2DPP8 | |
| SCHEMBL1381489 | 0.82 | DPP4 (0.52) | DPP4DPP9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560811-B9 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LAB (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1560811-B1 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LAB (US) | 2007-08-01 | — | — | EP | disclosed |