Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.72 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.51 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.50 |
| ▸ | FRK | P42685 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704264 | 0.88 | MAPK14 (0.83) | MAPK14HSPB1RAF1LYN | |
| SCHEMBL4704976 | 0.86 | MAPK14 (0.72) | MAPK14HSPB1RAF1LYN | |
| SCHEMBL4812425 | 0.84 | MAPK14 (1.00) | MAPK14HSPB1 | |
| SCHEMBL4701717 | 0.82 | MAPK14 (0.75) | MAPK14HSPB1EPHA3FRKRAF1 | |
| SCHEMBL4820863 | 0.75 | MAPK14 (0.74) | MAPK14HSPB1 | |
| SCHEMBL4702294 | 0.74 | MAPK14 (0.68) | MAPK14HSPB1 | |
| SCHEMBL4815165 | 0.74 | MAPK14 (1.00) | MAPK14HSPB1 | |
| SCHEMBL4818830 | 0.73 | MAPK14 (0.72) | MAPK14HSPB1 | |
| SCHEMBL4705471 | 0.73 | MAPK14 (0.83) | MAPK14HSPB1RAF1LYN | |
| SCHEMBL4700686 | 0.73 | MAPK14 (0.66) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436272-B1 | BIPHENYLCARBOXYLIC AMIDE DERIVATIVES AS P38 KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-05-07 | — | — | EP | claimed |