Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | KDM4A | O75164 | 2/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM6A | O15550 | 1/20 | 0.49 |
| ▸ | TET3 | O43151 | 1/20 | 0.49 |
| ▸ | KDM4B | O94953 | 1/20 | 0.49 |
| ▸ | KDM5C | P41229 | 1/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.49 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.49 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.49 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.49 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700756 | 0.88 | KDM4E (0.44) | KDM4EKDM4AEGLN1L3MBTL1KDM6B | |
| SCHEMBL13255537 | 0.78 | KDM4E (0.58) | KDM4EKDM4AEGLN1L3MBTL1KDM6B | |
| SCHEMBL4698503 | 0.77 | PDE4D (0.67) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL622498 | 0.77 | KDM4E (0.49) | KDM4EL3MBTL1RAB9AHTTNPC1 | |
| SCHEMBL13255421 | 0.76 | DHODH (0.52) | KDM4EKDM4AEGLN1L3MBTL1KDM6B | |
| Bromide SCHEMBL7367912 | 0.75 | KDM4E (0.47) | KDM4EL3MBTL1RAB9AHTTNPC1 | |
| SCHEMBL23725371 | 0.75 | HIF1A (0.48) | KDM4EKDM4AEGLN1L3MBTL1KDM6B | |
| SCHEMBL4033083 | 0.74 | KDM4E (0.68) | KDM4EKDM4AEGLN1L3MBTL1KDM6B | |
| SCHEMBL10156188 | 0.74 | KDM4E (0.42) | KDM4EL3MBTL1RAB9AHTTNPC1 | |
| SCHEMBL10156194 | 0.74 | MAPT (0.43) | KDM4EL3MBTL1RAB9AHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |
| CN-1148189-C | Quinoline carboxamides as TNF inhibitors and as PDC-IV inhibitors | ��������ķ������ | 2004-05-05 | — | — | CN | disclosed |
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| CN-1219131-A | Quinoline carboxamides as TNF inhibitors and as PDC-IV inhibitors | DARWIN DISCOVERY CO LTD (GB) | 1999-06-09 | — | — | CN | disclosed |
| US-5804588-A | TREATING DISEASES THAT ARE MODULATED BY INHIBITION OF PHOSPHODIESTERASE IV OR TUMOUR NECROSIS FACTOR | CHIROSCIENCE LIMITED (GB) | 1998-09-08 | — | — | US | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |