Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 18/20 | 0.55 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4861552 | 0.87 | TYK2 (0.58) | NR3C2JAK2TYK2 | |
| SCHEMBL26686506 | 0.83 | NR3C2 (0.54) | NR3C2 | |
| SCHEMBL30633341 | 0.83 | NR3C2 (0.54) | NR3C2 | |
| SCHEMBL24756094 | 0.81 | NR3C2 (0.55) | NR3C2 | |
| SCHEMBL15880595 | 0.79 | SMARCA2 (0.61) | NR3C2 | |
| SCHEMBL1437559 | 0.79 | NR3C2 (0.54) | NR3C2 | |
| SCHEMBL9749752 | 0.79 | NR3C2 (0.64) | NR3C2 | |
| SCHEMBL31078765 | 0.79 | AR (0.52) | NR3C2JAK2TYK2 | |
| SCHEMBL9278345 | 0.79 | SMARCA2 (0.65) | JAK2TYK2 | |
| SCHEMBL26185631 | 0.78 | NR3C2 (0.56) | NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455790-B1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1455790-B1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1560815-B1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-12 | — | — | EP | disclosed |
| EP-1587803-A1 | PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS | Aventis Pharma Deutschland GmbH (DE) | 2005-10-26 | — | — | EP | disclosed |
| EP-1560815-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | Aventis Pharma Deutschland GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| EP-1455790-A1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | Aventis Pharma Deutschland GmbH (DE) | 2004-09-15 | — | — | EP | disclosed |
| EP-1455790-A1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | Aventis Pharma Deutschland GmbH (DE) | 2004-09-15 | — | — | EP | disclosed |
| WO-2004060883-A1 | PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |
| WO-2004041788-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-21 | — | — | WO | disclosed |
| WO-2003049738-A1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-06-19 | — | — | WO | disclosed |
| WO-2003049738-A1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-06-19 | — | — | WO | disclosed |
| EP-0504799-B1 | Mixted pyridine-2,4- and 2,5-dicarboxylic acid diamides, process for their preparation, their use as well as medicaments based on these compounds | HOECHST AG (DE) | 1997-07-02 | — | — | EP | disclosed |
| EP-0602562-A1 | Process for the preparation of phthalocyanine reactive dyes | BASF Aktiengesellschaft (DE) | 1994-06-22 | — | — | EP | disclosed |
| EP-0587137-A1 | Adsorbate comparised of an auxiliary agent mixture and a non-solid active agent for the manufacture of pharmaceutical preparations | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-16 | — | — | EP | disclosed |
| EP-0504799-A1 | Mixted pyridine-2,4- and 2,5-dicarboxylic acid diamides, process for their preparation, their use as well as medicaments based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-09-23 | — | — | EP | disclosed |
| EP-0463592-A1 | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and for their utilization | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-02 | — | — | EP | disclosed |