Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.60 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698922 | 0.95 | PARP1 (0.66) | PARP1ARSMN1; SMN2ENPP1 | |
| Hydrochloric Acid SCHEMBL905525 | 0.94 | PARP1 (0.64) | PARP1ARSMN1; SMN2ENPP1 | |
| SCHEMBL4697385 | 0.92 | PARP1 (0.64) | PARP1ARTSHRCYP17A1CYP11B1 | |
| SCHEMBL4702188 | 0.79 | PARP1 (0.46) | PARP1ARSMN1; SMN2ENPP1 | |
| SCHEMBL905663 | 0.75 | FLT1 (0.46) | PARP1SMN1; SMN2 | |
| SCHEMBL12955553 | 0.74 | PARP1 (0.76) | PARP1ARTSHRSMN1; SMN2ENPP1 | |
| SCHEMBL4699720 | 0.72 | PARP1 (0.53) | PARP1ENPP1 | |
| SCHEMBL4700116 | 0.72 | PARP1 (0.57) | PARP1 | |
| SCHEMBL4699324 | 0.72 | HIF1A (0.55) | PARP1TSHRL3MBTL1 | |
| SCHEMBL6607498 | 0.71 | TSHR (0.56) | TSHRCYP17A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427708-B1 | AMINO-PHTHALAZINONE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER ITALIA SRL (IT) | 2008-09-10 | — | — | EP | disclosed |