Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.51 |
| ▸ | PIM1 | P11309 | 7/20 | 0.51 |
| ▸ | GSK3B | P49841 | 7/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.51 |
| ▸ | JAK2 | O60674 | 8/20 | 0.36 |
| ▸ | JAK1 | P23458 | 8/20 | 0.36 |
| ▸ | TYK2 | P29597 | 8/20 | 0.36 |
| ▸ | JAK3 | P52333 | 8/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213151 | 0.88 | PIK3CD (0.66) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL2214345 | 0.88 | PIK3CD (0.52) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL1960548 | 0.88 | PIK3CD (0.49) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL2213951 | 0.84 | PIK3CD (0.54) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL2214578 | 0.81 | PIK3CD (0.54) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL2212185 | 0.79 | PIK3CD (0.63) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL2212654 | 0.77 | PIK3CD (0.45) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL1251763 | 0.72 | PIK3CD (0.74) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL2212954 | 0.72 | PIK3CD (0.71) | PIK3CDPIK3CBPIM1GSK3BPIK3CG | |
| SCHEMBL458944 | 0.72 | PIK3CD (0.49) | PIK3CDPIK3CBPIM1GSK3BPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |
| WO-2011067364-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-06-09 | — | — | WO | disclosed |