Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646180 | 1.00 | DPP4 (0.77) | DPP4LMNAKDM4EABL1DPP8 | |
| SCHEMBL4703981 | 1.00 | DPP4 (0.77) | DPP4LMNAKDM4EABL1DPP8 | |
| SCHEMBL647706 | 0.88 | DPP4 (0.77) | DPP4DPP8DPP9CXCR3 | |
| SCHEMBL1381215 | 0.87 | DPP4 (0.81) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL647019 | 0.87 | DPP4 (0.81) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL648093 | 0.86 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL649897 | 0.85 | DPP4 (0.77) | DPP4LMNADPP8DPP9ALDH1A1 | |
| SCHEMBL647446 | 0.85 | DPP4 (0.77) | DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL6701734 | 0.84 | DPP4 (0.71) | DPP4DPP8DPP9DPP7HSD11B1 | |
| SCHEMBL645765 | 0.84 | DPP4 (0.56) | DPP4DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560811-B9 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LAB (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1560811-B1 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LAB (US) | 2007-08-01 | — | — | EP | disclosed |