Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 16/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046071 | 0.85 | BDKRB1 (0.68) | BDKRB1CCNA2CDK2CCNA1 | |
| SCHEMBL4703690 | 0.82 | BDKRB1 (0.66) | BDKRB1 | |
| SCHEMBL4790592 | 0.79 | BDKRB1 (0.68) | BDKRB1MEN1KMT2A | |
| SCHEMBL6046090 | 0.76 | BDKRB1 (0.72) | BDKRB1 | |
| SCHEMBL4705427 | 0.76 | BDKRB1 (0.58) | BDKRB1KMT2A | |
| SCHEMBL4702570 | 0.75 | BDKRB1 (0.65) | BDKRB1MEN1KMT2A | |
| SCHEMBL4715194 | 0.74 | BDKRB1 (0.60) | BDKRB1MEN1KMT2A | |
| SCHEMBL4703936 | 0.74 | BDKRB1 (0.55) | BDKRB1 | |
| SCHEMBL4702356 | 0.73 | BDKRB1 (0.56) | BDKRB1CCNA2CDK2CCNA1 | |
| SCHEMBL6045964 | 0.73 | BDKRB1 (0.74) | BDKRB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |