Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 14/20 | 0.64 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700707 | 0.94 | BDKRB1 (0.57) | BDKRB1GRM5NTRK1CHRM4CHRM2 | |
| SCHEMBL4700959 | 0.93 | BDKRB1 (0.57) | BDKRB1GRM5CHRM4 | |
| SCHEMBL4700946 | 0.93 | BDKRB1 (0.57) | BDKRB1GRM5NTRK1CHRM4 | |
| SCHEMBL4706708 | 0.92 | BDKRB1 (0.55) | BDKRB1NTRK1CHRM4CHRM2 | |
| SCHEMBL4705201 | 0.91 | BDKRB1 (0.66) | BDKRB1CHRM4 | |
| SCHEMBL4702570 | 0.91 | BDKRB1 (0.65) | BDKRB1 | |
| SCHEMBL6046064 | 0.87 | BDKRB1 (0.70) | BDKRB1NTRK1 | |
| SCHEMBL4705088 | 0.83 | BDKRB1 (0.78) | BDKRB1CHRM4CHRM2 | |
| SCHEMBL4700827 | 0.83 | BDKRB1 (0.69) | BDKRB1NTRK1CHRM4 | |
| SCHEMBL6046091 | 0.81 | BDKRB1 (0.62) | BDKRB1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |