Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 17/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683944 | 0.87 | GRM5 (0.69) | GRM5 | |
| SCHEMBL4703812 | 0.84 | GRM5 (0.63) | GRM5 | |
| SCHEMBL4703247 | 0.81 | GRM5 (0.63) | GRM5 | |
| SCHEMBL4699576 | 0.81 | GRM5 (0.58) | GRM5 | |
| SCHEMBL4698737 | 0.79 | GRM5 (0.68) | GRM5 | |
| SCHEMBL4702667 | 0.79 | GRM5 (0.63) | GRM5 | |
| SCHEMBL4698623 | 0.79 | GRM5 (0.61) | GRM5 | |
| SCHEMBL4702133 | 0.79 | GRM5 (0.67) | GRM5 | |
| SCHEMBL4699537 | 0.79 | GRM5 (0.65) | GRM5 | |
| SCHEMBL13683910 | 0.78 | GRM5 (1.00) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434773-B1 | HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | claimed |
| US-7253190-B2 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | disclosed |