Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704243 | 0.87 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4704462 | 0.83 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6589533 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4702285 | 0.79 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4701819 | 0.78 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586085 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699913 | 0.77 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699266 | 0.76 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699341 | 0.76 | PDE4D (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699329 | 0.76 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581229-B1 | PHTHALAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2008-03-12 | — | — | EP | claimed |