Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.52 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704839 | 0.87 | CHEK1 (0.55) | CHEK1IKBKBCDK2AP1 | |
| SCHEMBL4208186 | 0.86 | CHEK1 (0.63) | CHEK1ATML3MBTL1CDK2AP1 | |
| SCHEMBL4702677 | 0.85 | CHEK1 (0.55) | CHEK1IKBKBCDK2AP1 | |
| SCHEMBL4706724 | 0.83 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL4703022 | 0.83 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL4705785 | 0.83 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL4704773 | 0.82 | CHEK1 (0.53) | CHEK1IKBKB | |
| SCHEMBL4703464 | 0.82 | CHEK1 (0.61) | CHEK1CDK2AP1 | |
| SCHEMBL4704584 | 0.82 | CHEK1 (0.61) | CHEK1CDK2AP1 | |
| SCHEMBL4705590 | 0.82 | CHEK1 (0.61) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |