Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.54 |
| ▸ | CDK2AP1 | O14519 | 5/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704937 | 0.93 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL4707220 | 0.89 | CHEK1 (0.53) | CHEK1CDK2AP1 | |
| SCHEMBL4210886 | 0.88 | CHEK1 (0.55) | CHEK1CDK2AP1IKBKB | |
| SCHEMBL4704593 | 0.85 | CHEK1 (0.57) | CHEK1CDK2AP1IKBKB | |
| SCHEMBL4704879 | 0.85 | CHEK1 (0.62) | CHEK1CDK2AP1IKBKB | |
| SCHEMBL4702670 | 0.84 | CHEK1 (0.57) | CHEK1CDK2AP1 | |
| SCHEMBL4705745 | 0.84 | CHEK1 (0.57) | CHEK1CDK2AP1 | |
| SCHEMBL4991807 | 0.82 | CHEK1 (0.61) | CHEK1CDK2AP1 | |
| SCHEMBL4214940 | 0.82 | CHEK1 (0.78) | CHEK1CDK2AP1 | |
| SCHEMBL5001062 | 0.82 | CHEK1 (0.58) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |