Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.49 |
| ▸ | CTSD | P07339 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704656 | 0.86 | BACE1 (0.63) | BACE1BACE2CTSDAPP | |
| SCHEMBL4704875 | 0.83 | BACE1 (0.54) | BACE1BACE2CTSDAPP | |
| SCHEMBL4706443 | 0.82 | BACE1 (0.62) | BACE1BACE2CTSDAPP | |
| SCHEMBL4706748 | 0.81 | BACE1 (0.56) | BACE1BACE2CTSD | |
| SCHEMBL4706837 | 0.80 | BACE1 (0.63) | BACE1BACE2CTSDAPP | |
| SCHEMBL5146444 | 0.76 | BACE1 (0.74) | BACE1BACE2CTSDAPP | |
| SCHEMBL4704616 | 0.76 | BACE1 (0.62) | BACE1BACE2CTSDAPP | |
| SCHEMBL4790666 | 0.76 | BACE1 (0.55) | BACE1BACE2CTSDAPP | |
| SCHEMBL4706336 | 0.75 | BACE1 (0.75) | BACE1BACE2CTSD | |
| SCHEMBL4707604 | 0.75 | BACE1 (0.75) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966185-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION | Wyeth a Corporation of the State of Delaware (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007078813-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-07-12 | — | — | WO | disclosed |