Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757107 | 1.00 | MAPK14 (0.35) | MAPK14CTSAMEN1KMT2AGAA | |
| SCHEMBL4757853 | 1.00 | MAPK14 (0.35) | MAPK14CTSAMEN1KMT2AGAA | |
| SCHEMBL4707014 | 1.00 | MAPK14 (0.35) | MAPK14CTSAMEN1KMT2AGAA | |
| SCHEMBL4707388 | 1.00 | MAPK14 (0.35) | MAPK14CTSAMEN1KMT2AGAA | |
| SCHEMBL5795287 | 0.85 | SMN1; SMN2 (0.38) | MAPK14MEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL6205153 | 0.83 | SMN1; SMN2 (0.35) | MAPK14KMT2AGAASMN1; SMN2MTNR1A | |
| SCHEMBL4706018 | 0.80 | GAA (0.43) | MEN1KMT2AGAATP53LMNA | |
| SCHEMBL4706016 | 0.80 | GAA (0.43) | MEN1KMT2AGAATP53LMNA | |
| SCHEMBL5831107 | 0.77 | PTK2 (0.42) | MTNR1AMTNR1BMAPT | |
| SCHEMBL4707389 | 0.73 | MAPK14 (0.35) | MAPK14CTSAMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560832-B1 | PYRIMIDO 4,5-D PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | EP | claimed |