Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3038058 | 0.91 | PDE4B (0.57) | PDE4BMAPTIDO1SMN1; SMN2NPC1 | |
| SCHEMBL4708657 | 0.91 | PDE4B (0.73) | PDE4BMAPTHTR1AADRA1DADRA1A | |
| SCHEMBL4708694 | 0.91 | PDE4B (0.73) | PDE4BMAPTHTR1AADRA1DADRA1A | |
| SCHEMBL3029107 | 0.90 | PDE4B (0.56) | PDE4BMAPTNPC1RAB9ALMNA | |
| SCHEMBL4705519 | 0.89 | PDE4B (0.70) | PDE4BMAPTHTR1AADRA1DADRA1A | |
| SCHEMBL4708425 | 0.89 | PDE4B (0.72) | PDE4BMAPTHTR1AADRA1DADRA1A | |
| SCHEMBL4708776 | 0.88 | PDE4B (0.80) | PDE4BHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4707375 | 0.87 | PDE4B (0.70) | PDE4BMAPTHTR1AADRA1DADRA1A | |
| SCHEMBL4708875 | 0.87 | PDE4B (0.70) | PDE4BMAPTHTR1AADRA1DADRA1A | |
| SCHEMBL4058811 | 0.87 | PDE4B (0.70) | PDE4BMAPTHTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459453-B2 | Pyridazin-3(2H)-one derivatives as PDE4 inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-12-02 | — | — | US | disclosed |
| US-20080269235-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS | DAL PIAZ VITTORIO | 2008-10-30 | — | — | US | disclosed |
| US-20060052379-A1 | Pyridazin-3(2h)-one derivatives as pde4 inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269235-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS | PDE4A, PDE3A, PDE4B | PDE4B 3/4885MAPT 3692/4885IDO1 985/4885 |
| US-20060052379-A1 | Pyridazin-3(2h)-one derivatives as pde4 inhibitors | PDE4A, PDE3A, PDE4B | PDE4B 3/4885MAPT 3692/4885IDO1 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.