Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGPAT2 | O15120 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738127 | 0.88 | AGPAT2 (0.48) | AGPAT2NPC1SMN1; SMN2LMNARAB9A | |
| SCHEMBL29287111 | 0.79 | ADORA2A (0.39) | CDK9CDK5MAPK1HSP90AA1HTR2B | |
| SCHEMBL4286785 | 0.78 | RECQL (0.53) | AGPAT2NPC1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL17271571 | 0.74 | MGAM (0.45) | AGPAT2CDK9NPC1SMN1; SMN2KDM4E | |
| SCHEMBL2489752 | 0.74 | NPC1 (0.68) | AGPAT2CDK9NPC1SMN1; SMN2KDM4E | |
| SCHEMBL28302056 | 0.74 | ADORA2A (0.50) | NPC1SMN1; SMN2KDM4ELMNARAB9A | |
| SCHEMBL4291570 | 0.70 | HSP90AA1 (0.66) | AGPAT2CDK9NPC1SMN1; SMN2KDM4E | |
| SCHEMBL21801683 | 0.70 | ADORA2A (0.51) | NPC1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL17271570 | 0.70 | CDC7 (0.48) | AGPAT2CDK9MAPTPIM1IDO1 | |
| SCHEMBL21583424 | 0.69 | ADORA2A (0.54) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991550-A1 | AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Cellzome Limited (GB) | 2008-11-19 | — | — | EP | disclosed |
| EP-1860109-A1 | Azetidine amino pyrimidine compounds for the treatment of inflammatory disorders | Cellzome (UK) Ltd. (GB) | 2007-11-28 | — | — | EP | disclosed |
| EP-1860109-A1 | Azetidine amino pyrimidine compounds for the treatment of inflammatory disorders | Cellzome (UK) Ltd. (GB) | 2007-11-28 | — | — | EP | disclosed |
| EP-1860108-A1 | Enantiomers of Amino Pyrimidine compounds for the treatment of inflammatory disorders | Cellzome (UK) Ltd. (GB) | 2007-11-28 | — | — | EP | disclosed |
| EP-1860108-A1 | Enantiomers of Amino Pyrimidine compounds for the treatment of inflammatory disorders | Cellzome (UK) Ltd. (GB) | 2007-11-28 | — | — | EP | disclosed |
| EP-1829879-A1 | Amino pyrimidine compounds for the treatment of inflammatory disorders | Cellzome (UK) Ltd. (GB) | 2007-09-05 | — | — | EP | disclosed |
| EP-1829879-A1 | Amino pyrimidine compounds for the treatment of inflammatory disorders | Cellzome (UK) Ltd. (GB) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007090854-A1 | AZETIDINE AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME (UK) LTD. (GB) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007090853-A1 | ENANTIOMERS OF AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME (UK) LTD. (GB) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007090853-A1 | ENANTIOMERS OF AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME (UK) LTD. (GB) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007090852-A1 | AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME LIMITED (GB) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007090852-A1 | AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME LIMITED (GB) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007090854-A1 | AZETIDINE AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME (UK) LTD. (GB) | 2007-08-16 | — | — | WO | disclosed |