Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 5/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10225110 | 0.84 | SERPINE1 (0.39) | F10SERPINE1MAPTKDM4EMEN1 | |
| SCHEMBL46889 | 0.78 | F10 (0.37) | F10SERPINE1LRRK2MAPTKDM4E | |
| SCHEMBL46917 | 0.74 | LRRK2 (0.48) | F10LRRK2MAPTKMT2AKCNH2 | |
| SCHEMBL45411 | 0.74 | PPARG (0.38) | F10LRRK2MAPTKDM4EMEN1 | |
| SCHEMBL46569 | 0.73 | F10 (0.37) | F10SERPINE1LRRK2MAPTKDM4E | |
| SCHEMBL46914 | 0.70 | LRRK2 (0.43) | F10LRRK2CYP3A4 | |
| SCHEMBL46822 | 0.70 | MAPT (0.40) | F10SERPINE1MAPTKDM4EMEN1 | |
| SCHEMBL19013330 | 0.70 | F10 (0.48) | F10KCNH2 | |
| SCHEMBL19013492 | 0.70 | NPC1 (0.45) | F10SERPINE1MAPTMEN1KMT2A | |
| SCHEMBL16804934 | 0.69 | F10 (0.38) | F10SERPINE1LRRK2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |