Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.66 |
| ▸ | DPP7 | Q9UHL4 | 13/20 | 0.66 |
| ▸ | DPP8 | Q6V1X1 | 13/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709018 | 1.00 | DPP4 (0.66) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL5041276 | 0.86 | DPP4 (0.66) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL4710555 | 0.83 | DPP4 (0.66) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL4761344 | 0.80 | DPP4 (1.00) | DPP4DPP7DPP8 | |
| SCHEMBL4761339 | 0.80 | DPP4 (1.00) | DPP4DPP7DPP8 | |
| SCHEMBL12189888 | 0.79 | DPP4 (0.60) | DPP4DPP7DPP8KCNH2 | |
| Hydrochloric Acid SCHEMBL4709328 | 0.79 | DPP4 (0.98) | DPP4DPP7DPP8 | |
| SCHEMBL18331891 | 0.78 | DPP4 (0.73) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL8245497 | 0.77 | DPP4 (0.68) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL8245496 | 0.77 | DPP4 (0.68) | DPP4DPP7DPP8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651623-B1 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2008-12-17 | — | — | EP | disclosed |