Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 17/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709250 | 0.95 | DPP4 (0.37) | DPP4MAPK8TACR1F2RL3MAPK9 | |
| SCHEMBL4713395 | 0.94 | MAPK8 (0.44) | DPP4MAPK8TACR1MAPK9MAPK10 | |
| SCHEMBL4710297 | 0.92 | MAPK8 (0.42) | DPP4MAPK8MAPK9MAPK10 | |
| SCHEMBL4711356 | 0.91 | DPP4 (0.39) | DPP4MAPK8F2RL3MAPK9MAPK10 | |
| SCHEMBL4711627 | 0.89 | MAPK8 (0.47) | DPP4MAPK8MAPK9MAPK10 | |
| SCHEMBL4712496 | 0.85 | DPP4 (0.41) | DPP4MAPK8MAPK9MAPK10 | |
| SCHEMBL4709968 | 0.84 | MAPK8 (0.46) | MAPK8MAPK9MAPK10 | |
| SCHEMBL4712591 | 0.83 | MAPK8 (0.47) | DPP4MAPK8MAPK9MAPK10 | |
| SCHEMBL4711072 | 0.83 | MAPK8 (0.41) | MAPK8MAPK9MAPK10 | |
| SCHEMBL4710456 | 0.82 | MAPK8 (0.47) | DPP4MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402595-B2 | Enzyme inhibitors with isoquinolinone structures | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-22 | — | — | US | disclosed |
| US-20050148624-A1 | Jnk inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-07-07 | — | — | US | disclosed |
| EP-1484320-A1 | JNK INHIBITOR | Takeda Chemical Industries, Ltd. (JP) | 2004-12-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148624-A1 | Jnk inhibitor | MAPK3, MAPKAPK3, MAPK1 | DPP4 3669/4885MAPK8 5/4885TACR1 4613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.