Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.47 |
| ▸ | CTSD | P07339 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14862455 | 0.80 | BACE1 (0.49) | BACE1CTSDAKR1B1APPTP53 | |
| SCHEMBL4711816 | 0.79 | AKR1B1 (0.38) | BACE1CTSDAKR1B1KMT2A | |
| SCHEMBL2182582 | 0.79 | BACE1 (0.46) | BACE1CTSDAKR1B1APPMAPT | |
| SCHEMBL4713122 | 0.77 | AKR1B1 (0.49) | BACE1CTSDAKR1B1APPSMN1; SMN2 | |
| SCHEMBL4518818 | 0.77 | BACE1 (0.51) | BACE1CTSDAKR1B1APPMAPT | |
| SCHEMBL5333068 | 0.72 | BACE1 (0.43) | BACE1CTSDAKR1B1APPMAPT | |
| SCHEMBL6906553 | 0.69 | BACE1 (0.43) | BACE1CTSDAKR1B1MAPTSMN1; SMN2 | |
| SCHEMBL12299613 | 0.68 | BACE1 (0.42) | BACE1CTSDAKR1B1MAPTSMN1; SMN2 | |
| SCHEMBL14053723 | 0.68 | BACE1 (0.44) | BACE1CTSDAKR1B1APP | |
| SCHEMBL6915372 | 0.68 | BACE1 (0.41) | BACE1CTSDAKR1B1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008007210-A2 | NITROGENOUS N-SUBSTITUTED 4-SPIRO-HETEROCYCLIC 2, 2 -DIMETHYLCHROMANE DERIVATIVES | UNIVERSITA' DI PISA (IT) | 2008-01-17 | — | — | WO | disclosed |