Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.64 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527125 | 0.84 | GRM5 (0.77) | GRM5CYP26A1CYP3A4 | |
| SCHEMBL4710054 | 0.81 | GRM5 (0.56) | GRM5 | |
| SCHEMBL3640785 | 0.81 | CA12 (0.55) | GRM5CYP26A1CYP3A4 | |
| SCHEMBL14061545 | 0.80 | GRM5 (0.57) | GRM5 | |
| SCHEMBL15913469 | 0.80 | GRM5 (0.55) | GRM5 | |
| SCHEMBL14061548 | 0.80 | GRM5 (0.55) | GRM5 | |
| SCHEMBL8983698 | 0.80 | GRM5 (0.52) | GRM5CYP26A1CYP3A4 | |
| SCHEMBL19411346 | 0.79 | GRM5 (1.00) | GRM5 | |
| Hydrochloric Acid SCHEMBL23478508 | 0.78 | GRM5 (0.98) | GRM5 | |
| SCHEMBL4710109 | 0.77 | GRM5 (0.55) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |