Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 11/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5398230 | 0.94 | SMN1; SMN2 (0.51) | MAPTSMN1; SMN2TTKPDGFRBFLT1 | |
| SCHEMBL4655966 | 0.92 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2TTKCHRNA7PDGFRB | |
| SCHEMBL4712833 | 0.92 | TTK (0.50) | MAPTTTKCHRNA7 | |
| SCHEMBL5399718 | 0.90 | TTK (0.52) | SMN1; SMN2TTKMAPKAPK5 | |
| SCHEMBL5394669 | 0.89 | TTK (0.54) | MAPTSMN1; SMN2TTKCHRNA7PDGFRB | |
| SCHEMBL5416181 | 0.87 | TTK (0.51) | TTKCHRNA7 | |
| SCHEMBL5394670 | 0.87 | TTK (0.54) | MAPTSMN1; SMN2TTKMAPKAPK5 | |
| SCHEMBL5404932 | 0.85 | TTK (0.56) | MAPTTTKCHRNA7 | |
| SCHEMBL5396618 | 0.83 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2PDGFRBFLT1KDR | |
| SCHEMBL5405328 | 0.81 | CD274 (0.55) | SMN1; SMN2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991528-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2008-11-19 | — | — | EP | claimed |
| WO-2007098826-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2007-09-07 | — | — | WO | claimed |
| EP-1991528-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098826-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2007-09-07 | — | — | WO | disclosed |