Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.76 |
| ▸ | CAMK1D | Q8IU85 | 6/20 | 0.76 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.76 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.75 |
| ▸ | BTK | Q06187 | 1/20 | 0.75 |
| ▸ | ITK | Q08881 | 1/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | BLK | P51451 | 1/20 | 0.54 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.54 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29794661 | 0.87 | SYK (1.00) | SYKCAMK1DZAP70PRKCEBTK | |
| SCHEMBL1222899 | 0.87 | SYK (1.00) | SYKCAMK1DZAP70PRKCEBTK | |
| SCHEMBL4714405 | 0.84 | SYK (1.00) | SYKCAMK1DZAP70PRKCEBTK | |
| SCHEMBL29794721 | 0.84 | SYK (1.00) | SYKCAMK1DZAP70PRKCEBTK | |
| Hydrochloric Acid SCHEMBL4716050 | 0.81 | SYK (0.98) | SYKCAMK1DZAP70PRKCEBTK | |
| SCHEMBL2627353 | 0.80 | SYK (1.00) | SYKCAMK1DZAP70PRKCEBTK | |
| SCHEMBL1354032 | 0.80 | SYK (0.69) | SYKCAMK1DZAP70PRKCEBTK | |
| SCHEMBL4713199 | 0.79 | SYK (0.57) | SYKCAMK1DZAP70PRKCEBTK | |
| SCHEMBL1352407 | 0.79 | SYK (1.00) | SYKCAMK1DZAP70PRKCEBTK | |
| SCHEMBL1352412 | 0.79 | SYK (1.00) | SYKCAMK1DZAP70PRKCEBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054004-B1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-07-16 | — | — | EP | disclosed |
| US-6432963-B1 | ANTIINFLAMMATORY AGENTS; TYROSINE KINASE INHIBITOR | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1054004-A1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-11-22 | — | — | EP | disclosed |