Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.33 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810929 | 0.80 | PTGES2 (0.43) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| SCHEMBL30092382 | 0.77 | MAP3K14 (0.45) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| SCHEMBL471131 | 0.77 | MAP3K14 (0.45) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| Acetic Acid SCHEMBL4631030 | 0.75 | FFAR1 (0.48) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| SCHEMBL4968126 | 0.73 | CYP3A4 (0.58) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| SCHEMBL14177740 | 0.72 | MAPT (0.43) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| SCHEMBL1507506 | 0.72 | CYP3A4 (0.50) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| SCHEMBL29433431 | 0.72 | CYP3A4 (0.50) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| SCHEMBL11442991 | 0.71 | FFAR1 (0.40) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 | |
| SCHEMBL13964107 | 0.70 | HSD17B2 (0.40) | FFAR1HCRTR1ADRB2RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168581-A9 | Stable polymorph of N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof | OSI Pharmaceuticals, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2168581-A2 | Stable polymorph of N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof | OSI Pharmaceuticals, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |