Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 16/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MC5R | P33032 | 2/20 | 0.42 |
| ▸ | MC3R | P41968 | 2/20 | 0.42 |
| ▸ | MC1R | Q01726 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15078325 | 0.83 | MC4R (0.57) | MC4RNPC1MC5RMC3RMC1R | |
| SCHEMBL41222 | 0.80 | MC4R (0.60) | MC4RNPC1MC5RMC3RMC1R | |
| SCHEMBL15078321 | 0.79 | MC4R (0.55) | MC4RNPC1MC5RMC3RMC1R | |
| SCHEMBL47157 | 0.78 | MC4R (0.51) | MC4RNPC1MC5RMC3RMC1R | |
| SCHEMBL47154 | 0.78 | MC4R (0.49) | MC4RNPC1MC5RMC3RMC1R | |
| SCHEMBL40944 | 0.78 | MC4R (0.57) | MC4RNPC1MC5RMC3RMC1R | |
| SCHEMBL46875 | 0.75 | MC4R (0.65) | MC4RMC5RMC3RMC1RBCHE | |
| SCHEMBL47152 | 0.75 | MC4R (0.62) | MC4RMC5RMC3RMC1RBCHE | |
| SCHEMBL47195 | 0.75 | MC4R (0.64) | MC4RMC5RMC3RMC1RBCHE | |
| SCHEMBL47114 | 0.74 | MC4R (0.69) | MC4RMC5RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003576-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal (CA) | 2012-01-12 | — | — | WO | disclosed |