Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 7/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 3/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12206746 | 1.00 | KCNH2 (0.58) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL1104532 | 0.90 | KCNH2 (0.59) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL29388566 | 0.89 | KCNH2 (0.71) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL22546665 | 0.89 | KCNH2 (0.71) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL839658 | 0.89 | KCNH2 (0.71) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL24491222 | 0.89 | KCNH2 (0.71) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL310422 | 0.89 | KCNH2 (0.71) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL840053 | 0.89 | KCNH2 (0.71) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL29989600 | 0.89 | KCNH2 (0.71) | KCNH2SCN3ABTKFFAR2SCN1A | |
| SCHEMBL2832640 | 0.88 | KCNH2 (0.63) | KCNH2SCN3AFFAR2SCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943216-A1 | PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007042250-A1 | PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |