Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 3/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 8/20 | 0.41 |
| ▸ | HTR2C | P28335 | 8/20 | 0.41 |
| ▸ | HTR2B | P41595 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138610 | 0.85 | KCNQ3 (0.50) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E | |
| SCHEMBL3142636 | 0.81 | KCNQ3 (0.41) | KCNQ3KCNQ2KCNE1KCNQ1HTR2A | |
| SCHEMBL3138625 | 0.74 | KCNQ3 (0.49) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E | |
| SCHEMBL6179288 | 0.73 | KCNQ3 (0.53) | KCNQ3KCNQ2KCNE1KCNQ1HTR2A | |
| SCHEMBL6180870 | 0.73 | KCNQ3 (0.57) | KCNQ3KCNQ2KCNE1KCNQ1HTR2C | |
| SCHEMBL14496838 | 0.73 | KCNQ3 (0.40) | KCNQ3KCNQ2KCNE1KCNQ1HTR2A | |
| SCHEMBL3027034 | 0.73 | MEN1 (0.48) | KDM4EUSP2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3129054 | 0.72 | PRKAA2 (0.51) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E | |
| SCHEMBL12522866 | 0.71 | KCNQ3 (0.55) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E | |
| SCHEMBL3062018 | 0.71 | HRH3 (0.46) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957073-A2 | MEDICINAL DRUG | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007066784-A2 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-06-14 | — | — | WO | disclosed |
| EP-1773797-A2 | AROMATIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014012-A2 | AROMATIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-02-09 | — | — | WO | disclosed |