Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 12/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.68 |
| ▸ | RAB9A | P51151 | 9/20 | 0.68 |
| ▸ | NPC1 | O15118 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.68 |
| ▸ | RELA | Q04206 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | POLB | P06746 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714503 | 1.00 | MEN1 (0.68) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL4713486 | 0.85 | MEN1 (0.51) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL4713488 | 0.85 | MEN1 (0.51) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL4715311 | 0.83 | MEN1 (0.52) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL4715307 | 0.83 | MEN1 (0.52) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL4710779 | 0.81 | MEN1 (0.49) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL4710778 | 0.81 | MEN1 (0.49) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL13646963 | 0.78 | MEN1 (0.61) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL4713161 | 0.78 | MEN1 (0.67) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL4713163 | 0.78 | MEN1 (0.67) | MEN1KMT2ARAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |