Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.74 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | CNR2 | P34972 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717650 | 1.00 | TDP1 (0.97) | TDP1KMT2AMEN1TP53NPBWR1 | |
| SCHEMBL11711932 | 0.98 | TDP1 (1.00) | TDP1KMT2AMEN1TP53NPBWR1 | |
| SCHEMBL5100491 | 0.86 | TDP1 (0.78) | TDP1KMT2AMEN1TP53NPBWR1 | |
| SCHEMBL4716079 | 0.85 | TDP1 (0.76) | TDP1KMT2AMEN1TP53SMN1; SMN2 | |
| SCHEMBL11160156 | 0.85 | TDP1 (0.76) | TDP1KMT2AMEN1TP53NPBWR1 | |
| SCHEMBL11818635 | 0.85 | TDP1 (0.71) | TDP1KMT2AMEN1TP53NPBWR1 | |
| SCHEMBL5510039 | 0.84 | TDP1 (0.69) | TDP1KMT2AMEN1TP53NPBWR1 | |
| SCHEMBL4251116 | 0.84 | TDP1 (0.69) | TDP1KMT2AMEN1TP53SMN1; SMN2 | |
| SCHEMBL11185044 | 0.84 | MAPK1 (0.77) | TDP1KMT2ATP53SMN1; SMN2RAB9A | |
| SCHEMBL5623047 | 0.84 | MAPK1 (0.77) | TDP1KMT2ATP53SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615904-B1 | SUBSTITUTED BENZOSULPHONAMIDES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ASTRAZENECA AB (SE) | 2008-02-27 | — | — | EP | claimed |
| EP-1615904-B1 | SUBSTITUTED BENZOSULPHONAMIDES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ASTRAZENECA AB (SE) | 2008-02-27 | — | — | EP | disclosed |
| US-7297796-B2 | Sulfamoyl benzamide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2007-11-20 | — | — | US | disclosed |
| US-7297796-B2 | Sulfamoyl benzamide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2007-11-20 | — | — | US | disclosed |
| US-7297796-B2 | Sulfamoyl benzamide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2007-11-20 | — | — | US | disclosed |
| WO-2006044645-A2 | SULFAMOYL BENZAMIDES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |
| US-20060079557-A1 | Sulfamoyl benzamide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2006-04-13 | — | — | US | disclosed |
| US-4029787-A | Basically substituted 3-sulfamoylbenzoic acid derivatives and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079557-A1 | Sulfamoyl benzamide derivatives and methods of their use | CNR2, TRPV1, CNR1 | TDP1 4314/4885KMT2A 1089/4885MEN1 3148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.