Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22208127 | 0.86 | POLB (0.46) | PDE7AEPHX2HRH3POLBHSD17B10 | |
| SCHEMBL6119281 | 0.84 | PDE7A (0.41) | PDE7AEPHX2HRH3POLBSIGMAR1 | |
| SCHEMBL3020717 | 0.84 | CHRM1 (0.40) | HRH3POLBSIGMAR1CHRM1MEN1 | |
| SCHEMBL606752 | 0.84 | CHRM1 (0.40) | HRH3POLBSIGMAR1CHRM1MEN1 | |
| SCHEMBL3020178 | 0.84 | CHRM1 (0.40) | HRH3POLBSIGMAR1CHRM1MEN1 | |
| SCHEMBL25404533 | 0.84 | PDE7A (0.41) | PDE7AEPHX2HRH3POLBSIGMAR1 | |
| SCHEMBL3013245 | 0.83 | HRH3 (0.40) | HRH3POLBHSD17B10SIGMAR1CHRM1 | |
| SCHEMBL3013240 | 0.83 | HRH3 (0.40) | HRH3POLBHSD17B10SIGMAR1CHRM1 | |
| SCHEMBL3586086 | 0.83 | HRH3 (0.40) | HRH3POLBHSD17B10SIGMAR1CHRM1 | |
| SCHEMBL3229882 | 0.82 | EPHX2 (0.51) | EPHX2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004182-A1 | BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-24 | — | — | EP | disclosed |
| EP-1996189-A1 | BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007107567-A1 | BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007107565-A1 | BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |