Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 18/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.47 |
| ▸ | AKT1 | P31749 | 9/20 | 0.47 |
| ▸ | AKT2 | P31751 | 9/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 9/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | RPS6KA1 | Q15418 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4719810 | 0.99 | RPS6KA5 (0.68) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4715729 | 0.93 | RPS6KA5 (0.69) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL4717601 | 0.93 | RPS6KA5 (0.68) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4718838 | 0.86 | RPS6KA5 (0.70) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4714845 | 0.85 | RPS6KA5 (0.66) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4717535 | 0.82 | RPS6KA5 (1.00) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4718720 | 0.81 | RPS6KA5 (0.55) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4714615 | 0.81 | RPS6KA5 (0.64) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4717336 | 0.81 | RPS6KA5 (0.57) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4719638 | 0.81 | RPS6KA5 (0.59) | RPS6KA5ROCK1AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |
| EP-1490367-A1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080610-A1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |