Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.47 |
| ▸ | KDR | P35968 | 15/20 | 0.47 |
| ▸ | MET | P08581 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14540837 | 0.88 | KDR (0.50) | BRAFKDRMET | |
| SCHEMBL14540841 | 0.85 | BRAF (0.52) | BRAFKDRMET | |
| SCHEMBL1891544 | 0.83 | KDR (0.58) | BRAFKDR | |
| SCHEMBL1891287 | 0.81 | KDR (0.52) | BRAFKDRRIPK3FGFR1 | |
| SCHEMBL4327777 | 0.80 | BRAF (0.51) | BRAFKDR | |
| SCHEMBL1889996 | 0.79 | KDR (0.61) | BRAFKDR | |
| SCHEMBL4335519 | 0.78 | MEN1 (0.47) | BRAFKDRMET | |
| SCHEMBL4334102 | 0.77 | KDR (0.51) | BRAFKDRMETRIPK3 | |
| SCHEMBL4335858 | 0.76 | KDR (0.58) | BRAFKDR | |
| SCHEMBL16037156 | 0.76 | KDR (0.56) | BRAFKDRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506962-B1 | Nitrogen-containing aromatic heterocycles | EISAI R&D MAN CO LTD (JP) | 2008-07-02 | — | — | EP | claimed |