Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | MARS1 | P56192 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | TXK | P42681 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4712552 | 0.99 | MAPKAPK2 (0.56) | MAPKAPK2LOXL2KDM4EALDH1A1KDM5A | |
| SCHEMBL14188284 | 0.94 | MAPKAPK2 (0.64) | MAPKAPK2LOXL2KDM4EALDH1A1KDM5A | |
| Trifluoroacetic Acid SCHEMBL4714469 | 0.88 | MAPKAPK2 (0.58) | MAPKAPK2LOXL2KDM4EALDH1A1KDM5A | |
| SCHEMBL14188353 | 0.87 | MAPKAPK2 (0.58) | MAPKAPK2LOXL2MARS1PDE4APDE4B | |
| Hydrochloric Acid SCHEMBL4718376 | 0.86 | MAPKAPK2 (0.57) | MAPKAPK2LOXL2MARS1PDE4APDE4B | |
| SCHEMBL4712817 | 0.86 | MAPKAPK2 (0.55) | MAPKAPK2LOXL2KDM4EALDH1A1KDM5A | |
| Hydrochloric Acid SCHEMBL4715203 | 0.85 | MAPKAPK2 (0.54) | MAPKAPK2LOXL2KDM4EALDH1A1KDM5A | |
| SCHEMBL14188347 | 0.81 | MAPKAPK2 (0.50) | MAPKAPK2ALDH1A1MAPT | |
| SCHEMBL14188450 | 0.81 | MAPKAPK2 (0.52) | MAPKAPK2KDM5AKDM4CKDM5BHDAC1 | |
| Hydrochloric Acid SCHEMBL4714314 | 0.81 | MAPKAPK2 (0.52) | MAPKAPK2KDM5AKDM4CKDM5BHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| EP-1572682-A4 | ACYCLIC PYRAZOLE COMPOUNDS | PHARMACIA CORP (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1572682-A2 | ACYCLIC PYRAZOLE COMPOUNDS | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004058176-A2 | ACYCLIC PYRAZOLE COMPOUNDS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | MAPKAPK2 2/4885LOXL2 2696/4885KDM4E 2647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.