Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 12/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | ARAF | P10398 | 3/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718589 | 0.92 | BRAF (0.47) | ABL1BRAFRAF1ARAFPIKFYVE | |
| SCHEMBL4713627 | 0.90 | ABL1 (0.48) | ABL1BRAFRAF1ARAFMAP3K7 | |
| SCHEMBL14572597 | 0.85 | BRAF (0.55) | BRAFRAF1ARAFMAP3K7MAP4K2 | |
| SCHEMBL14572600 | 0.84 | BRAF (0.49) | ABL1BRAFRAF1ARAFMAP3K7 | |
| SCHEMBL4714607 | 0.84 | MAP3K7 (0.39) | BRAFRAF1MAP3K7MAP4K2MAPK14 | |
| SCHEMBL14572598 | 0.84 | LCK (0.57) | BRAFRAF1ARAFMAPK14 | |
| SCHEMBL3386095 | 0.83 | MAP4K2 (0.63) | ABL1RAF1MAP3K7MAP4K2MAPK14 | |
| SCHEMBL3388912 | 0.80 | MAP3K7 (0.52) | ABL1BRAFRAF1ARAFMAP3K7 | |
| SCHEMBL3386984 | 0.80 | CSF1R (0.58) | BRAFRAF1ARAFPIKFYVE | |
| SCHEMBL14572593 | 0.79 | BRAF (0.54) | BRAFRAF1ARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891066-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-02-27 | — | — | EP | claimed |
| WO-2006124462-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2006-11-23 | — | — | WO | claimed |