Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 15/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386114 | 0.90 | EGFR (0.56) | EGFRSYKAURKBKCNH2ZAP70 | |
| SCHEMBL2385591 | 0.89 | SYK (0.69) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL2627348 | 0.88 | SYK (0.47) | SYKNFKB1AKR1C3AKR1C2 | |
| SCHEMBL2386728 | 0.88 | STAT6 (0.59) | EGFRSYKAURKBKCNH2ZAP70 | |
| SCHEMBL2386230 | 0.84 | SYK (0.59) | EGFRSYKAURKBKCNH2ZAP70 | |
| SCHEMBL4711606 | 0.84 | SYK (0.48) | SYKAURKBKCNH2ZAP70AKR1C3 | |
| SCHEMBL10251065 | 0.82 | AKR1C3 (0.51) | SYKAURKBKCNH2ZAP70NFKB1 | |
| SCHEMBL2627208 | 0.81 | SYK (0.54) | SYKZAP70 | |
| SCHEMBL27615184 | 0.81 | SYK (0.47) | SYKAURKBKCNH2ZAP70 | |
| SCHEMBL9945496 | 0.81 | EGFR (0.61) | EGFRSYKNFKB1AURKAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054004-B1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-07-16 | — | — | EP | disclosed |
| US-6432963-B1 | ANTIINFLAMMATORY AGENTS; TYROSINE KINASE INHIBITOR | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1054004-A1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-11-22 | — | — | EP | disclosed |