Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | CEL | P19835 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | PDE8B | O95263 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15103664 | 0.98 | HRH4 (0.40) | HRH4CDK2MAPTTDP1PDE2A | |
| SCHEMBL15103587 | 0.79 | PDE2A (0.41) | PDE2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3210565 | 0.72 | HSP90AB1 (0.47) | HRH4MAPT | |
| SCHEMBL26907059 | 0.71 | PDE2A (0.40) | PDE2AKCNH2PDE4APDE4BPDE4C | |
| SCHEMBL29770674 | 0.71 | PDE2A (0.40) | PDE2AKCNH2PDE4APDE4BPDE4C | |
| SCHEMBL20671956 | 0.71 | CDK2 (0.40) | HRH4CDK2PNPHTR3AMCHR1 | |
| SCHEMBL18616362 | 0.71 | CDK2 (0.40) | HRH4CDK2PNPHTR3AMCHR1 | |
| SCHEMBL7454742 | 0.70 | KDM5B (0.43) | HRH4KCNH2PDE4APDE4BPDE4C | |
| SCHEMBL5468464 | 0.70 | MAPT (0.71) | CDK2MAPTTDP1 | |
| SCHEMBL17625285 | 0.70 | MAPT (0.41) | CDK2MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896428-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OP GABA B MEDIATED NERVOUS SYSTEM DISORDERS | Novartis AG (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006136442-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OP GABA B MEDIATED NERVOUS SYSTEM DISORDERS | NOVARTIS AG (CH) | 2006-12-28 | — | — | WO | disclosed |