Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 19/20 | 0.90 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.90 |
| ▸ | AKT1 | P31749 | 12/20 | 0.90 |
| ▸ | AKT2 | P31751 | 12/20 | 0.90 |
| ▸ | AKT3 | Q9Y243 | 11/20 | 0.90 |
| ▸ | RPS6KA1 | Q15418 | 6/20 | 0.90 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.90 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.90 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | PRKX | P51817 | 2/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719834 | 0.95 | RPS6KA5 (1.00) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL25220176 | 0.94 | RPS6KA5 (0.98) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4714419 | 0.84 | RPS6KA5 (0.77) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL14252538 | 0.84 | RPS6KA5 (0.75) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4762992 | 0.83 | RPS6KA5 (0.80) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL14252574 | 0.82 | RPS6KA5 (0.91) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4761491 | 0.82 | RPS6KA5 (0.64) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL4715800 | 0.81 | RPS6KA5 (0.89) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL6645116 | 0.81 | RPS6KA5 (0.89) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL4716741 | 0.81 | RPS6KA5 (0.89) | RPS6KA5ROCK1AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |